
NFC West rivals clash on the Week 10 edition of Monday Night Football as the 3-5 San Francisco 49ers host the 7-2 Los Angeles Rams. The Rams need a win tonight to tie the Cardinals record atop the NFC West, while the 49ers desperately need a quality win to keep their playoff hopes alive.
The spread in this game is surprisingly tight, but should it be? As always, we’re here to give you advice before you bet the spread, points, or props including anytime touchdown scorer. Once you’ve got the picks, find the best site to place your bets with our list of the Best Football Betting Sites .

Levi Stadium host the NFLβs Week 10 edition of Monday Night Football
The spread has bounced around a little bit, but stayed surprisingly tight considering one of these teams has seven wins and the other has three. Don’t forget that two of those wins came in the first two weeks of the season, meaning the 49ers are 1-5 in their last six games with their only win coming against the Bears.
However, the 49ers have been the Ram’s, and Sean McVay’s kryptonite as they’ve won the last five contests between these two teams. This year could be different for the Rams. For one they’ve gotten an upgrade at QB with Matt Stafford under center. They are also plugging in their latest addition to the offense, Odell Beckham Jr. at Wide Receiver following a season-ending injury to Robert Woods.
Both teams come into this game off of losses, the Rams were stifled by the defense of the Tennessee Titans, and the 49ers let up 31 points to the Kyler Murray-less Arizona Cardinals. Home field advantage may not mean much seeing that the Rams are 4-0 on the road this year, while the 49er’s are 1-11 at home over the past two seasons. That one win coming against… the Los Angeles Rams.
Divisional matchups can always be a little wacky to predict, but the Rams are too good of a team to not take here. Take them in the moneyline and give up the 3.5 points on the spread as well.
Best Bonus
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) Call 877-8-HOPENY or text HOPENY (467369) (NY) Call 1-800-327-5050 (MA) 21+ only. Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). Rewards are non-withdrawable bonus bets that expire in 7 days. In partnership with Kansas Crossing Casino and Hotel. See BetMGM.com for Terms. US promotional offers not available in DC, Mississippi, New York, Nevada, Ontario, or Puerto Rico.
Newcomer
Get $300 Back in Bonus Bets Every Day For 10 Days
Gambling Problem? Call 1-800-GAMBLER or visit RG Help . Call 1-888-789-7777 or visit Helpline and Chat β CONNECTICUT COUNCIL (CT). Hope is here. MA Gambling Helpline or call (800) 327-5050 for 24/7 support (MA). Visit Home (MD). Call 1-877-8HOPE-NY or text HOPENY (467369) (NY) 21+ (18+ D.C., KY, WY) and present in select states (for KS, in affiliation with Kansas Star Casino). First online real money wager only. $5 first deposit required. Bonus issued as nonwithdrawable bonus bets which expire 7 days after receipt. Restrictions apply. See terms at FanDuel Sportsbook
In the eight games prior to their loss last week, the Rams were averaging over 30 points. The 49ers on the other hand have averaged just over 20. Take those two numbers, add them up, and you’re right at 50. Still, this game doesn’t have the feel of a shootout. The 49er’s haven’t shown an ability to put up points at will so far this season, and divisional rivalries end up being defensive slogs more often than high flying score fests. Take the under here.
Strange to see this TE with such high odds to score a touchdown, but that’s what happens when you get injured and miss a solid chunk of the NFL season. Still, if the 49ers have a prayer of winning this game Kittle will need to be heavily involved. For that reason, I’d put money on him to get into the endzone.
For a riskier pick, go with Brandon Aiyuk at +260. He got off to a slow start, but has seen seven and eight targets in his last two games. San Fran should have to throw the ball quite a bit in this one as well.
Do we get back to the days of George Kittle dominance? If San Fran wants to be successful they better hope so. Coming off of a eight target, six reception game Kittle looks healthy and will continue to be a focal point of this offense.
Make the most off of your bets by
taking advantage of the great offers and deals located on our Betting Bonuses Page
.
Here’s just a sampling of the offers you’ll find:
Recommended
4.6/5
Requirements (WR):
–
Min. Deposit:
$5
Min. Odds:
BetMGM Bonus
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Players from Virginia accepted
T&Cs apply, 21+
Copy
Payment Methods
Withdrawal
0 β 3 Days
Apps
License
Award
GGA – Digital Operator of the Year (2023)
Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) Call 877-8-HOPENY or text HOPENY (467369) (NY) Call 1-800-327-5050 (MA) 21+ only. Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). Rewards are non-withdrawable bonus bets that expire in 7 days. In partnership with Kansas Crossing Casino and Hotel. See BetMGM.com for Terms. US promotional offers not available in DC, Mississippi, New York, Nevada, Ontario, or Puerto Rico.
Show less
Hot Offer
4.5/5
Requirements (WR):
1x Deposit
Min. Deposit:
5
Min. Odds:
FanDuel Bonus
Get $300 Back in Bonus Bets Every Day For 10 Days
Players from Virginia accepted
T&Cs apply, 21+
Go to FanDuel
Payment Methods
Withdrawal
1 β 10 Days
Apps
License
Award
Global Gaming Awards (2022)
Gambling Problem? Call 1-800-GAMBLER or visit RG Help . Call 1-888-789-7777 or visit Helpline and Chat β CONNECTICUT COUNCIL (CT). Hope is here. MA Gambling Helpline or call (800) 327-5050 for 24/7 support (MA). Visit Home (MD). Call 1-877-8HOPE-NY or text HOPENY (467369) (NY) 21+ (18+ D.C., KY, WY) and present in select states (for KS, in affiliation with Kansas Star Casino). First online real money wager only. $5 first deposit required. Bonus issued as nonwithdrawable bonus bets which expire 7 days after receipt. Restrictions apply. See terms at FanDuel Sportsbook
Show less
Hot Offer
4.5/5
Requirements (WR):
1x Deposit
Min. Deposit:
–
Min. Odds:
Caesars Bonus
Up to $250 Bonus Bet
Players from Virginia accepted
T&Cs apply, 21+
Copy
Payment Methods
Withdrawal
0 β 5 Days
Apps
License
21+ New users only. Must register using eligible promo code. First bet after registration must qualify. Max. Bonus Bet: $1,000. Bonus Bet expires 14 days after receipt. Void where prohibited. See Caesars.com/promos for full terms. Gambling Problem? 1-800-GAMBLER (1-800-426-2537)
Show less
4.
4.5/5
Requirements (WR):
–
Min. Deposit:
5
Min. Odds:
DraftKings Bonus
New Customers: Bet $5+ Get $200 in Bonus Bets Instantly
Players from Virginia accepted
T&Cs apply, 21+
Go to DraftKings
Payment Methods
Withdrawal
0 β 5 Days
Apps
License
Award
EGR – Operator of the year (2023)
GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/KY/NH/PR/WY). Void in NH/OR/ONT/PR. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new customer. Min. $5 first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets that expire in 7 days (168 hours). Stake removed from payout. Plus, upon qualifying bet placement, get 1 100% Profit Boost Token, valid only for a NCAA Tournament Winner bet. Max. Bet: $10. Profit Boost Tokens are single-use and expire on 4/6/26 at 11:59 PM ET. Must select Token BEFORE placing bet. Boost only applies to winnings. Ends 4/6/26 11:59 PM ET. Terms: Promos | DraftKings Sportsbook
Show More
5.
4.5/5
Requirements (WR):
–
Min. Deposit:
–
Min. Odds:
Fanatics Bonus
Bet $50, Get $300 in FanCash
Players from Virginia accepted
T&Cs apply, 21+
Go to Fanatics
Payment Methods
Apps
License
Must be 21+. GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-522-4700, Home (MD), (800)-327-5050 or MA Gambling Helpline (MA), Call (877)8-HOPENY or text HOPENY (467369) (NY), or Call 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), (888) 789-7777 or CONNECTICUT COUNCIL β ON PROBLEM GAMBLING (CT), or 1-800-9-WITH-IT (IN), If gambling is more than a game, free help is available . . . – NCDHHS Problem Gambling (NC). New customers in AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA, MA, MD, MI, MO, NC, NJ, NY, OH, PA, TN, VA, VT, WV, or WY. Must opt-in and wager $10+ cash on any market with odds of -500 or longer to receive $100 in FanCash each day for your first 3 days (issued when qualifying wager settles). Your 3 days begin the day you establish your account. FanCash rewards expire at 11:59 p.m. ET 7 days from issuance. Terms, including FanCash terms, apply – see Fanatics Sportsbook app.
Show More
Requirements (WR):
–
Min. Deposit:
–
Min. Odds:
Hard Rock Bet Bonus
Double Your Winnings on Your First 10 Bets! $50 Max Bets
Players from Virginia accepted
21+ | T&C apply | Gambling Problem? Call 1-800-GAMBLER.
Best Alternative
Go to BetMGM
Payment Methods
Apps
License
To be eligible, the Player must be at least 21 years old, physically located in an Eligible Jurisdiction: AZ, CO, IL, IN, MI, NJ, OH, TN, or VA, and not on any exclusionary lists in any Eligible Jurisdiction. Excluded patrons are prohibited from participating in Promotions. To be eligible all personal and contact data associated to your account must be verifiable. GAMBLING PROBLEM Arizona Customers: Call 1-800-NEXT-STEP or Text NEXTSTEP to 53342. Colorado, Illinois, Michigan, New Jersey, Ohio, and Virginia Customers: Call 1-800-GAMBLER Indiana Customers: Call 1-800-9-WITH-IT Tennessee Customers: Call or text the Tennessee REDLINE: 1-800-889-9789
Show More
Requirements (WR):
–
Min. Deposit:
–
Min. Odds:
Barstool Bonus
Players from Virginia accepted
T&Cs apply, 21+
Best Alternative
Go to BetMGM
Payment Methods
Withdrawal
1 β 5 Days
Apps
License
Show More

21+ and present in VA. Gambling Problem? Call 1-800-GAMBLER.